Modafinil (marketed as Provigil® in the U.S.) is a novel wake-promoting stimulant with low abuse potential used to treat excessive sleepiness and narcolepsy ( Bastuji and Jouvet, 1988). These results suggest that modafinil’s effects of memory are more selective than amphetamine or cocaine, and specific to hippocampus-dependent memory. Pre-training modafinil did not affect cued conditioning at any dose tested, and immediate post-training modafinil had no effect on either cued or contextual fear. A low dose of pre-training modafinil (0.75 mg/kg) enhanced memory of contextual fear conditioning (tested off-drug one week later) while a high dose (75 mg/kg) disrupted memory. We also examined modafinil (0.075 – 75 mg/kg) on Pavlovian fear conditioning. When given only before testing, modafinil did not affect water maze performance. A high dose of modafinil (75 mg/kg, i.p.) given before training improved acquisition on a Morris water maze. The current study aims to further examine the effects of modafinil as a cognitive enhancer on hippocampus-dependent memory in mice. Because of many similarities, the mechanism of action may be comparable to classical psychostimulants, although the exact mechanisms of modafinil’s actions in wakefulness and cognitive enhancement are unknown. Modafinil has been shown to promote wakefulness and some studies suggest the drug can improve cognitive function.
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